Endocrine Abstracts

Type 2 diabetes mellitus (T2DM) is characterized by major disturbances in lipids as well as the defining abnormalities in glucose. In spite of this, our understanding of the control of lipid metabolism is incomplete. In particular, the relative contribution of insulin compared to other regulatory inputs to the determination of liver and total body adiposity is unclear. We have used a loss of function approach to study the requirement for a major downstream target of insulin, t...